Pathology in CWD-Infected Animals
(A) Histologic lesions of CWD in the dorsal motor nuclei of the vagus nerve within the medulla oblongata of a CWD-affected elk. Note spongiform change, intraneuronal vacuoles, and mild gliosis (hematoxylin and eosin stain, 1003 magnification).
(B) PrP amyloid deposit stained by immunohistochemistry (brown) and surrounded by vacuoles (original magnification 1803).
(C) Perineuronal and extracellular deposits of abnormal PrP (PrPCWD, analogous to PrPSc) in a CWD-affected mule deer (original magnification1803).
(D) PrPCWD deposits in the germinal centres of lymphoid follicles in the tonsils of a mule deer (immunohistochemistry, original magnification 503). PLoS Pathogens DOI:10.1371/journal.ppat.0020026.g002
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