Monkeypox in Gambian pouched rats
Autor/Urheber:
Falendysz EA, Lopera JG, Lorenzsonn F, Salzer JS, Hutson CL, Doty J, Gallardo-Romero N, Carroll DS, Osorio JE, Rocke TE.
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Gross lesions of Gambian pouched rats (Cricetomys gambianus) infected with MPXV/Luc+.
A. GPR 5, 14 days after infection with Monkeypox Virus expressing luciferase (MPXV/Luc+) with a vesicle on the tongue (red circle), necrotic gingivitis (white arrow) and a vesicle that has opened and crusted (black arrow). B. The left eye of GPR 1 with white-yellow corneal opacities (black arrow) and ocular discharge (white arrow). C The abdomen of GPR 5, 14 days after infection, with prominent ribs and folds of skin which show severe weight loss, as well as many skin vesicles on the abdomen. Luminescence (fig 3) is visible in all of these areas and there were high levels of viral shedding in the conjunctival/corneal swabs taken from GPR 1, as well as in oral swabs taken from GPR 5.
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Credit:
"Further Assessment of Monkeypox Virus Infection in Gambian Pouched Rats (Cricetomys gambianus) Using In Vivo Bioluminescent Imaging". PLoS Negl Trop Dis. 2015 Oct 30;9(10):e0004130. doi: 10.1371/journal.pntd.0004130. PMID: 26517839; PMCID: PMC4627722. Via Openi
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