Hepatitis B virus v2
- The 6 nm[2] thick outer viral envelope or membrane contains host-derived lipids and surface proteins,[2] known collectively as HBsAg.[3] The membrane contains globular subunits each measuring ca. 3 to 4 nm in diameter and 3 to 4 nm apart.[2]
- Within the membrane sphere is a 2 nm thick icosahedral nucleocapsid inner core composed of protein (HBcAg) with a 27 nm diameter.[2] When viewed through an electron microscope the inner core may appear pentagonal or hexagonal,[2] depending on the relative position of the sample.
- The nucleocapsid contains a viral genome[2] of circular, partially double stranded DNA[3] and endogenous DNA polymerase[4][3] within a diameter of ca. 18 nm.[2]
The virion was initially referred to as the Dane particle.[4] Only after Baruch Blumberg received the Nobel Prize in Medicine during 1976 was it universally accepted that the particle is a virus and the infectious agent of Hepatitis B.
Australia antigen (HBsAg): The serum of infected patients contain small spherical and rod-shaped particles with a diameter of ca. 20 nm,[5] consisting of surplus virus-coat material containing the HBsAg antigen.[1][2] This antigen was first discovered by Baruch Blumberg during 1965 within the blood of Australian aboriginal people and initially known as "Australia antigen".[6] It was shown to be associated with "serum hepatitis" by A. M. Prince during 1968.[7]
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Hepatitis-B-VirusDas Hepatitis-B-Virus (HBV) ist ein behülltes DNA-Virus mit überwiegend doppelsträngigem Genom und der Auslöser der Hepatitis B. Das Hepatitis-B-Virus entstammt der Gattung Orthohepadnavirus innerhalb der Familie der Hepadnaviridae. .. weiterlesen